Integrins alpha v beta 3 and alpha v beta 5 contribute to cell attachment to vitronectin but differentially distribute on the cell surface.

We investigated the role of the integrins alpha v beta 3 and alpha v beta 5 in mediating vitronectin adhesion of three phenotypically distinct cell types. M21 human melanoma cells and H2981 lung carcinoma cells use both alpha v-containing integrins in adhering to vitronectin while UCLA-P3 lung carcinoma cells adhere exclusively with alpha v beta 5. Specifically, monoclonal antibodies directed to functional epitopes on both receptors were required to block adhesion of M21 or H2981 cells while adhesion of UCLA-P3 cells to vitronectin could be blocked with a monoclonal antibody to alpha v beta 5. Although both receptors are involved in M21 and H2981 cell adhesion to vitronectin, only alpha v beta 3 can be detected in focal contacts, colocalizing with vinculin, talin, and the ends of actin filaments, while alpha v beta 5 shows a distinct, nonfocal contact, distribution on the cell surface. These results provide the first evidence that two homologous integrins that recognize the same ligand distribute differentially on the cell surface

EVASÃO ESCOLAR: NO CURSO DE LETRAS – LIBRAS DA UFSC

Aborda-se neste artigo, o tema Evasão Escolar. O presente estudo está delimitado para o Curso de Letras – Libras da UFSC e tem como objetivo analisar as causas da evasão escolar desta nova carreira na UFSC. Para tanto, caracterizou-se o presente trabalho como pesquisa qualitativa, que possibilita a tradução daquilo que não pode ser mensurável. Quanto ao nível da pesquisa, trata-se de uma pesquisa descritiva, que analisa o tema, pois observou-se, registrou-se e correlacionou-se os aspectos relevantes da mesma. Utilizou-se como procedimentos a pesquisa bibliográfica e pesquisa webgráfica. Concluiu-se com a pesquisa que as principais causas da evasão no Curso de Letras - Libras da UFSC, provêm da falta de comunicação eficaz institucional e compreensão da realidade e expectativas do aluno surdo por parte dos professores, colegas e tutores

Similarity and income content at the international trade: The case of BRICS during the period 2000/09

This study aimed to calculate the patterns of similarity and income content of Brazilian, Russian, Chinese and Indian exports by means of indexes, and compare those patterns with those of OECD countries, covering a period between 2000 and 2009. The results indicate that Brazilian, Russian, Chinese and Indian exports became more similar between 2000 and 2006, but that similarity has declined ever since. Exports from China and India, in turn, are increasingly similar to each other and less different from the exports of OECD countries. Export sophistication has increased over the years, with higher growth rates in China and India. India and Russia's sophistication indexes surpassed that of Brazil in 2007, which signal that those countries currently export products with higher content of income. The study also indicated that Brazil has been losing market share for China and India as an exporter of sophisticated products. --Exports,Brazil,Russia,China,India,similarity,income content

Materialização da experiência artística em substrato têxtil

Dissertação de mestrado em Design e MarketingA Arte sempre acompanhou a evolução do tempo. Retratando épocas, os artistas assumiram um papel de narradores pictóricos, atribuindo à arte diversas funções: mágicas, representativas, práticas e de celebração, didácticas e explicativas, estéticas e cognitivas. Actualmente, a arte assume funções educativas, políticas, sociais e mercantis. Novos instrumentos, característicos da nossa época, têm vindo a ser experimentados em busca do conhecimento das suas possibilidades como meios para transmitir um pensamento actual, de modo mais completo, mais claro e o mais universal possível, acentuando a função experimental da arte. A colocação da indústria têxtil ao serviço da arte e o consequente recurso a processos de produção industrial para a materialização das obras, permite ao artista dotar-se de meios que melhor satisfaçam as suas «fantasias». No trabalho experimental realizado ao longo do presente projecto, ficou demonstrada a adequação de substratos têxteis em obras de artes, quer ao nível da capacidade expressiva quer ao nível da funcionalidade do objecto de arte. A utilização de suportes utilitários, nomeadamente suportes têxteis e a produção em pequenas séries, permite cumprir a necessidade de fazer chegar a obra a um público mais vasto. Assim concretizada, a obra torna-se um objecto com carga simbólica e, ao mesmo tempo, conserva a funcionalidade do seu suporte. Pretende-se com isso que o seu fruidor defina o seu uso, seja quotidiano ou contemplativo. A obra de arte aproxima-se intimamente do seu público, o qual a pode usufruir, ou não, enquanto objecto simbólico.The art has always followed the evolution of civilizations. By portraying historical periods, artists assumed an important role as pictorial narrators. Arts perform several functions: magic, representative, functional and celebratory, educational and explanatory, aesthetic and cognitive. Nowadays, art performs educational, political social and commercial functions. New tools are being experimented by artists who are engaged in discovering their capability to express the spirit of our time. They try today, as they always have, to find new means to communicate their aesthetic experiences in a more complete, clear and universal way, enhancing the experimental function of art. Textile industries and materials give the artist the possibility to use industrial production to materialize his work of art. In fact, this resource offers the artist new means to express his fantasies. The experimental work developed in this project demonstrated the capability of textile materials and technologies to fulfill the expression needs of the artist without losing their functional performance as textile objects. Using functional objects as expression subtract, namely textile products made in small runs, allows the artist to reach a broader audience. The resulting object assumes the symbolic meaning without losing its practical function. This way, the user can define how he enjoys the object: as a work of art, as a functional object or both

Cost-effectiveness analysis of a system-based approach for managing neonatal jaundice and preventing kernicterus in Ontario

OBJECTIVE: To evaluate the incremental cost-effectiveness of a system-based approach for the management of neonatal jaundice and the prevention of kernicterus in term and late-preterm (≥35 weeks) infants, compared with the traditional practice based on visual inspection and selected bilirubin testing. STUDY DESIGN: Two hypothetical cohorts of 150,000 term and late-preterm neonates were used to compare the costs and outcomes associated with the use of a system-based or traditional practice approach. Data for the evaluation were obtained from the case costing centre at a large teaching hospital in Ontario, supplemented by data from the literature. RESULTS: The per child cost for the system-based approach cohort was $176, compared with$173 in the traditional practice cohort. The higher cost associated with the system-based cohort reflects increased costs for predischarge screening and treatment and increased postdischarge follow-up visits. These costs are partially offset by reduced costs from fewer emergency room visits, hospital readmissions and kernicterus cases. Compared with the traditional approach, the cost to prevent one kernicterus case using the system-based approach was $570,496, the cost per life year gained was$26,279, and the cost per quality-adjusted life year gained was $65,698. CONCLUSION: The cost to prevent one kernicterus case using the system-based approach is much lower than previously reported in the literature. ©2012 Pulsus Group Inc. All rights reserved

Income Content of the World Coffee Exports

Coffee is the most widely commercialized tropical product on the international market. The 2009/10 crop had an estimated value of $15.4 billion, with 93.4 million bags exported. According to the International Coffee Organization (ICO, 2011), the coffee sector employed  around 26 million people in 56 producing countries and over 100 exporting countries. But how would coffee products rank, in terms of income content, in relation to other commercialized products, and how have they evolved? To answer this question, the annual income content of 5,111 products exported by 167 countries from the period between 2000 and 2009, was calculated. Data from the UNCOMTRADE (2011), and “sophistication” indicators proposed by Hausmann and Rodrik (2003) who classify different products according to their productivity, were used. An emphasis was put on five coffee products (whole grain, roasted, decaffeinated, caffeinated, and soluble), showing the evolution of the number of exporting countries and of the “sophistication” index (income content), whose temporal variation was decomposed by the effects of competitiveness and income per capita changes. The results showed that non-roasted, non-decaffeinated, whole grain coffee is still the most commercialized product, but with the lowest income content of all coffee products, occupying the twenty-fourth worst position in terms of income content in 2009. The roasted, decaffeinated coffee presented the greatest income growth in the period, placing itself in the 3,309th position in 2009. The decomposition of the index showed that for coffee products with the most processing, the greatest cause of export sophistication growth was the Revealed Comparative Advantage effect. Products with the least amount of processing presented a loss in relative market share, with the addition of values to the production chain occurring outside those countries producing the raw materials.El café es el producto tropical más comercializado en el mercado internacional. La cosecha de 2009/10 fue estimada en 15,4 mil millones de dólares, con 93,4 millones de sacos exportados. Según la Organización Internacional del Café (ICO, 2011), el sector cafetero ha empleado alrededor de 26 millones de personas en 56 países productores y en más de 100 países exportadores. Sin embargo, ¿cómo los tipos de café podrían ser clasificados, en cuanto al ingreso, en relación a otros productos comercializados, y cómo han evolucionado? Para contestar a esta pregunta, se han calculado los ingresos anuales de 5.111 productos exportados por 167 países en el período comprendido entre 2000 y 2009. Los datos fueron obtenidos a través del UNCOMTRADE (2011), y se han utilizado los indicadores de "sofisticación" propuestos por Hausmann y Rodrik (2003) que clasifican los diferentes productos en función de sus productividades. Se hizo especial hincapié en cinco tipos de café (grano entero, tostado, descafeinado, con cafeína y soluble), que muestra la evolución del número de países exportadores y del índice de "sofisticación" (relacionado a los ingresos), cuya variación temporal se ha descompuesto por los efectos de la competitividad y por los cambios en la renta per cápita. Los resultados mostraron que el café sin tostar, con cafeína y de grano entero sigue siendo el más comercializado, pero presenta el nivel más bajo de ingreso de todos los tipos de café, ocupando el vigésimo cuarto puesto de peor nivel de ingreso en 2009. El café tostado y descafeinado presentó el mayor crecimiento de ingresos en el período, ubicándose en el puesto 3309º en 2009. La descomposición del índice mostró que para los tipos de café con mayor procesamiento, la principal causa del crecimiento de la sofisticación de las exportaciones fue el efecto de la ventaja comparativa revelada. Los productos con menor cantidad de procesamiento presentaron una pérdida de cuota relativa de mercado, con el valor añadido a la cadena de producción llevado a cabo afuera de los países productores de materias primas

Contenido de la Renta de las exportaciones mundiales de café

Coffee is the most widely commercialized tropical product on the international market. The 2009/10 crop had an estimated value of $15.4 billion, with 93.4 million bags exported. According to the International Coffee Organization (ICO, 2011), the coffee sector employed around 26 million people in 56 producing countries and over 100 exporting countries. But how would coffee products rank, in terms of income content, in relation to other commercialized products, and how have they evolved? To answer this question, the annual income content of 5,111 products exported by 167 countries from the period between 2000 and 2009, was calculated. Data from the UNCOMTRADE (2011), and “sophistication” indicators proposed by Hausmann and Rodrik (2003) who classify different products according to their productivity, were used. An emphasis was put on five coffee products (whole grain, roasted, decaffeinated, caffeinated, and soluble), showing the evolution of the number of exporting countries and of the “sophistication” index (income content), whose temporal variation was decomposed by the effects of competitiveness and income per capita changes. The results showed that non-roasted, non-decaffeinated, whole grain coffee is still the most commercialized product, but with the lowest income content of all coffee products, occupying the twenty-fourth worst position in terms of income content in 2009. The roasted, decaffeinated coffee presented the greatest income growth in the period, placing itself in the 3,309th position in 2009. The decomposition of the index showed that for coffee products with the most processing, the greatest cause of export sophistication growth was the Revealed Comparative Advantage effect. Products with the least amount of processing presented a loss in relative market share, with the addition of values to the production chain occurring outside those countries producing the raw materials.El café es el producto tropical más comercializado en el mercado internacional. La cosecha de 2009/10 fue estimada en 15,4 mil millones de dólares, con 93,4 millones de sacos exportados. Según la Organización Internacional del Café (ICO, 2011), el sector cafetero ha empleado alrededor de 26 millones de personas en 56 países productores y en más de 100 países exportadores. Sin embargo, ¿cómo los tipos de café podrían ser clasificados, en cuanto al ingreso, en relación a otros productos comercializados, y cómo han evolucionado? Para contestar a esta pregunta, se han calculado los ingresos anuales de 5.111 productos exportados por 167 países en el período comprendido entre 2000 y 2009. Los datos fueron obtenidos a través del UNCOMTRADE (2011), y se han utilizado los indicadores de "sofisticación" propuestos por Hausmann y Rodrik (2003) que clasifican los diferentes productos en función de sus productividades. Se hizo especial hincapié en cinco tipos de café (grano entero, tostado, descafeinado, con cafeína y soluble), que muestra la evolución del número de países exportadores y del índice de "sofisticación" (relacionado a los ingresos), cuya variación temporal se ha descompuesto por los efectos de la competitividad y por los cambios en la renta per cápita. Los resultados mostraron que el café sin tostar, con cafeína y de grano entero sigue siendo el más comercializado, pero presenta el nivel más bajo de ingreso de todos los tipos de café, ocupando el vigésimo cuarto puesto de peor nivel de ingreso en 2009. El café tostado y descafeinado presentó el mayor crecimiento de ingresos en el período, ubicándose en el puesto 3309º en 2009. La descomposición del índice mostró que para los tipos de café con mayor procesamiento, la principal causa del crecimiento de la sofisticación de las exportaciones fue el efecto de la ventaja comparativa revelada. Los productos con menor cantidad de procesamiento presentaron una pérdida de cuota relativa de mercado, con el valor añadido a la cadena de producción llevado a cabo afuera de los países productores de materias primas